Changes in certain indicators of rat blood erythrocytes under the influence of histamine and quercetin

The influence of histamine and quercetin, as well their combined effect on the content in whole blood, superoxide anion radical, sialic acids, sulfhydryl groups, activity catalase, glutathione peroxidase, transferase rat erythrocytes was studied. It established that quercetin at a concentration 0.1 mM causes an increase blood rats, while all other studied concentrations cause significant decrease biogenic amine. Adding to 1 μM leads endogenous 10 μM, it this exogenous mainly amount rats. In erythrocytes, generation radical. An radical occurs under 0.1; action amine 0.01 product decreases. intensifies formation addition flavonoid therapeutic concentration. acids. Such also found µM 0.5; 3; 5 mM. acids erythrocytes. Addition except for mM, which indicator Histamine 0.01; SH-groups, – decrease. against background exposure groups. degree effect, is same groups independent weak indicated indicators has more pronounced effect. most Quercetin catalase activity, flavonoid, with 0.3; enzyme. activates (at µM) reduces hemolysates only 1; enhances peroxidase. Simultaneous 3 results intensification 0.3 does not change glutathione-S-transferase, mM) significantly dose-dependently activate glutathione-S-transferase. histamine, µM, enzyme erythrocyte compared samples added, but glutathione-S-transferase values ​​did reach control limits. Compared control, increases simultaneous quercetin. administration into powerful work peroxidase